![\"\"](\"https:\/\/biostatistics.med.uoa.gr\/wp-content\/uploads\/2025\/05\/Picture1.png\")
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\u03a4\u03af\u03c4\u03bb\u03bf\u03c2: Joint modeling of longitudinal and competing-risk data using cumulative incidence functions for the failure submodels accounting for potential failure cause misclassification through double sampling<\/p>\n
Abstract:<\/p>\n
Most of the literature on joint modeling of longitudinal and competing-risk data is based on cause-specific hazards, although modeling of the cumulative incidence function (CIF) is an easier and more direct approach to evaluate the prognosis of an event. We propose a flexible class of shared parameter models to jointly model a normally distributed marker over time and multiple causes of failure using CIFs for the survival submodels, with CIFs depending on the \u201ctrue\u201d marker value over time (i.e., removing the measurement error). The generalized odds rate transformation is applied, thus a proportional subdistribution hazards model is a special case. The requirement that the all-cause CIF should be bounded by 1 is formally considered. The proposed models are extended to account for potential failure cause misclassification, where the true failure causes are available in a small random sample of individuals. We also provide a multistate representation of the whole population by defining mutually exclusive states based on the marker values and the competing risks. Based solely on the assumed joint model, we derive fully Bayesian posterior samples for state occupation and transition probabilities. The proposed approach is evaluated in a simulation study and, as an illustration, it is fitted to real data from people with HIV.<\/p>\n<\/div>\n
AUEB-NKUA-Indiana Conference in Biostatistics & Health Analytics<\/strong><\/span><\/p>\n 4-6 July, Aegina Island<\/p>\n We are pleased to announce the first AUEB-NKUA-Indiana Conference on Biostatistics & Health Analytics. This conference is within the broader collaboration between the The Fairbanks School of Public Health, the School of Public Health in Bloomington of Indiana University and the Department of Statistics of Athens University of Economics and Business (AUEB-Stats) and the National and Kapodistrian University of Athens (NKUA) School of Medicine.<\/p>\n The morning sessions of the conference are devoted in three 3-hour short courses on Interim monitoring of clinical trials, Adaptive Designs and <\/em>Multivariable Analysis: Confounding or Interaction? How Much Complexity?<\/em><\/p>\n The conference is open for poster presentations from students and researchers with interest in Biostatistics and Health Analytics.<\/p>\n Details can be found here https:\/\/aueb-analytics.wixsite.com\/biostats-conf<\/a><\/p>\n Registration is now available here https:\/\/aueb-analytics.wixsite.com\/biostats-conf\/registration<\/a><\/p>\n \u03a0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u0394\u03b9\u03b4\u03b1\u03ba\u03c4\u03bf\u03c1\u03b9\u03ba\u03ae\u03c2 \u0394\u03b9\u03b1\u03c4\u03c1\u03b9\u03b2\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c8\u03b7\u03c6\u03af\u03bf\u03c5 \u03b4\u03b9\u03b4\u03ac\u03ba\u03c4\u03bf\u03c1\u03bf\u03c2 \u03a7\u03c1\u03ae\u03c3\u03c4\u03bf\u03c5 \u0398\u03c9\u03bc\u03b1\u03b4\u03ac\u03ba\u03b7<\/strong><\/u><\/p>\n \u03a3\u03b1\u03c2 \u03c0\u03c1\u03bf\u03c3\u03ba\u03b1\u03bb\u03bf\u03cd\u03bc\u03b5 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u0394\u03b9\u03b4\u03b1\u03ba\u03c4\u03bf\u03c1\u03b9\u03ba\u03ae\u03c2 \u0394\u03b9\u03b1\u03c4\u03c1\u03b9\u03b2\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c8\u03b7\u03c6\u03af\u03bf\u03c5 \u03b4\u03b9\u03b4\u03ac\u03ba\u03c4\u03bf\u03c1\u03bf\u03c2 \u03a7\u03c1\u03ae\u03c3\u03c4\u03bf\u03c5 \u0398\u03c9\u03bc\u03b1\u03b4\u03ac\u03ba\u03b7 \u03bc\u03b5 \u03c4\u03af\u03c4\u03bb\u03bf:<\/p>\n \u00abStatistical modeling of CD4 cell count evolution in HIV-positive individuals before and after antiretroviral treatment initiation under missing data due to various dropout mechanisms\u00bb<\/strong><\/span><\/p>\n \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03b8\u03b1 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c3\u03c4\u03bf \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03a5\u03b3\u03b9\u03b5\u03b9\u03bd\u03ae\u03c2, \u0395\u03c0\u03b9\u03b4\u03b7\u03bc\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 & \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03a3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 (\u03ba\u03c4\u03ae\u03c1\u03b9\u03bf 12, 2\u03bf \u03cc\u03c1\u03bf\u03c6\u03bf\u03c2) \u03c3\u03c4\u03b9\u03c2 10\/06\/2022<\/strong> \u03ba\u03b1\u03b9 \u03ce\u03c1\u03b1 13:00\u03bc\u03bc<\/strong><\/p>\n \u0397 \u03c4\u03c1\u03b9\u03bc\u03b5\u03bb\u03ae\u03c2 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c4\u03c1\u03bf\u03c0\u03ae<\/p>\n \u0393\u03b9\u03ce\u03c4\u03b1 \u03a4\u03bf\u03c5\u03bb\u03bf\u03cd\u03bc\u03b7 (\u0395\u03c0\u03b9\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03c3\u03b1)<\/p>\n Loukia Meligkotsidou<\/p>\n \u039a\u03c9\u03bd\u03c3\u03c4\u03b1\u03bd\u03c4\u03af\u03bd\u03bf\u03c2 \u0393\u03b9\u03b1\u03bd\u03bd\u03bf\u03cd\u03c4\u03c3\u03bf\u03c2<\/p>\n \u00a0\u0394\u0399\u0391\u039b\u0395\u039e\u0395\u0399\u03a3\u00a0<\/strong><\/u>\u03a3\u03a4\u039f \u03a0\u0391\u039d. \u0391\u0398\u0397\u039d\u03a9\u039d \u03a4\u0395\u039b\u0395\u03a5\u03a4\u0391\u0399\u0391 \u03a4\u03a1\u0399\u0391 \u0395\u03a4\u0397<\/strong><\/u><\/p>\n \u00a0\u03a0\u0391\u039b\u0391\u0399\u039f\u03a4\u0395\u03a1\u0395\u03a3\u00a0<\/strong><\/u>\u0394\u0399\u0391\u039b\u0395\u039e\u0395\u0399\u03a3 \u03a0\u039f\u03a5 \u0395\u0393\u0399\u039d\u0391\u039d \u03a3\u03a4\u039f \u03a0\u0391\u039d. \u0391\u0398\u0397\u039d\u03a9\u039d<\/strong><\/u><\/p>\n ","protected":false},"excerpt":{"rendered":" \u0395\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7: “\u0392\u03b9\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u0395\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b7 \u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03a5\u03b3\u03b5\u03af\u03b1\u03c2: \u03a3\u03c0\u03bf\u03c5\u03b4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u0395\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03a0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2” \u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03bc\u03ad\u03c3\u03c9 Webex: https:\/\/tinyurl.com\/biostat25 Facebook event: https:\/\/tinyurl.com\/biostat25event Linkedin event: https:\/\/tinyurl.com\/biostat25linkedin 2nd Conference in Biostatistics & Health Analytics 7-9 \u0399\u03bf\u03c5\u03bb\u03af\u03bf\u03c5 2025, \u0391\u03af\u03b3\u03b9\u03bd\u03b1 \u0395\u03af\u03bc\u03b1\u03c3\u03c4\u03b5 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c5\u03c7\u03ac\u03c1\u03b9\u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03ba\u03bf\u03b9\u03bd\u03ce\u03c3\u03bf\u03c5\u03bc\u03b5 \u03c4\u03bf 2\u03bf \u03a3\u03c5\u03bd\u03ad\u03b4\u03c1\u03b9\u03bf \u03c3\u03c4\u03b7 \u0392\u03b9\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae & \u0391\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03a5\u03b3\u03b5\u03af\u03b1\u03c2. \u03a4\u03bf \u03c3\u03c5\u03bd\u03ad\u03b4\u03c1\u03b9\u03bf \u03b1\u03c5\u03c4\u03cc \u03b8\u03b1 \u03b4\u03b9\u03b5\u03c1\u03b5\u03c5\u03bd\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c3\u03c4\u03b1\u03cd\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0392\u03b9\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 Read more about \u0395\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u2013 \u039f\u03bc\u03b9\u03bb\u03af\u03b5\u03c2<\/span>[…]<\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/pages\/172"}],"collection":[{"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/comments?post=172"}],"version-history":[{"count":34,"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/pages\/172\/revisions"}],"predecessor-version":[{"id":3203,"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/pages\/172\/revisions\/3203"}],"wp:attachment":[{"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/media?parent=172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"http:\/\/biostatistics.med.uoa.gr\/wp-content\/uploads\/2022\/06\/conference_image-300x75.png\")
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