{"id":1477,"date":"2021-04-26T15:07:47","date_gmt":"2021-04-26T12:07:47","guid":{"rendered":"http:\/\/biostatistics.med.uoa.gr\/?p=1477"},"modified":"2021-04-26T15:08:16","modified_gmt":"2021-04-26T12:08:16","slug":"method-development-genetics","status":"publish","type":"post","link":"https:\/\/biostatistics.med.uoa.gr\/en\/method-development-genetics\/","title":{"rendered":"Method development in human statistical genetics"},"content":{"rendered":"
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Applications are invited for a\u00a0<\/span><\/span>PhD<\/span><\/span>\u00a0fellowship\/scholarship at Graduate School of Technical Sciences,\u00a0<\/span><\/span>Aarhus<\/span><\/span>\u00a0University, Denmark, within the Department of Quantitative Genetics and Genomics (QGG)\u00a0<\/span><\/span>PhD<\/span><\/span>\u00a0programme. The position is available from 1 August 2021 or later.<\/span><\/span><\/p>\n

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Title: Method development in human statistical genetics<\/span><\/p>\n<\/div>\n

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Research area and project description:<\/span><\/p>\n<\/div>\n

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The\u00a0PhD<\/span>\u00a0will be supervised by Professor Doug Speed, and based at the Department of Quantitative Genetics and Genomics (QGG) at\u00a0Aarhus<\/span>\u00a0University. Dr. Speed’s research involves developing\u00a0methods<\/span>\u00a0for better analysing data from genome-wide association studies, with a particular focus on improving our understanding of human complex traits (e.g., physical traits such as height and BMI, or common diseases such as schizophrenia and epilepsy). Dr. Speed has developed the software LDAK (www.ldak.org<\/a>).<\/span><\/p>\n<\/div>\n

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The aim of the\u00a0PhD<\/span>\u00a0is to develop new\u00a0methods<\/span>\u00a0with the following goals: to identify causal loci (i.e., find genetic variant that influence phenotypes); to construct prediction models (be able to predict an individuals phenotypes from their genetic information); or to understand genetic architecture (investigate the biological mechanisms underlying complex traits). These\u00a0methods<\/span>\u00a0will then be applied to large-scale datasets (e.g., 100,000s of individuals from UK Biobank). Please see the LDAK website and the following three references for examples of previous\u00a0methods<\/span>:<\/span><\/p>\n<\/div>\n

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MultiBLUP: improved SNP-based prediction for complex traits (2015) PMID: 24963154 44<\/span><\/p>\n<\/div>\n

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Reevaluation of SNP heritability in complex human traits (2017) PMID: 28530675<\/span><\/p>\n<\/div>\n

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SumHer better estimates the SNP heritability of complex traits (2019) PMID: 30510236<\/span><\/p>\n<\/div>\n

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Qualifications and specific competences:<\/span><\/p>\n<\/div>\n

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The applicant must have an Bachelors degree and a MSC degree (or similar). As the project involves applied statistics, the applicant should have strong knowledge of statistics (e.g., a degree in mathematics, statistics, genetics or closely-related subjects). The applicant should ideally have some coding experience (e.g., in R, Stata, Matlab, C, etc). For applicants originally trained in mathematics or statistics, it will be desirable to have had previous experience in genetics, but not necessary. The applicant must be fluent in English, both oral and in writing.<\/span><\/p>\n<\/div>\n

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Place of employment and place of work:<\/span><\/p>\n<\/div>\n

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The\u00a0PhD<\/span>\u00a0will be based in the QGG, which is a major center for research and education in quantitative genetics and quantitative genomics\u00a0https:\/\/qgg.au.dk\/en\/<\/a>. QGG is an international research center with about 70 employees and visiting researchers from over 15 nations. Its members perform research within human genetics, livestock and plant breeding. It has buildings in Foulum, Flakkebjerg and on the main campus in\u00a0Aarhus<\/span>\u00a0center. The\u00a0PhD<\/span>\u00a0candidate is expected to be at the\u00a0Aarhus<\/span>\u00a0Campus.<\/span><\/p>\n<\/div>\n

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Contacts:<\/span><\/p>\n<\/div>\n

Applicants seeking further information are invited to contact\u00a0doug@qgg.au.dk<\/a><\/span><\/span><\/p>\n<\/div>\n

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\u00a0<\/span><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Applications are invited for a\u00a0PhD\u00a0fellowship\/scholarship at Graduate School of Technical Sciences,\u00a0Aarhus\u00a0University, Denmark, within the Department of Quantitative Genetics and Genomics (QGG)\u00a0PhD\u00a0programme. The position is available from 1 August 2021 or later. Title: Method development in human statistical genetics \u00a0 Research area and project description: The\u00a0PhD\u00a0will be supervised by Professor Doug Speed, and based at the Read more about Method development in human statistical genetics<\/span>[…]<\/a><\/p>","protected":false},"author":1,"featured_media":1057,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,15],"tags":[],"_links":{"self":[{"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/posts\/1477"}],"collection":[{"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/comments?post=1477"}],"version-history":[{"count":1,"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/posts\/1477\/revisions"}],"predecessor-version":[{"id":1478,"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/posts\/1477\/revisions\/1478"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/media\/1057"}],"wp:attachment":[{"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/media?parent=1477"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/categories?post=1477"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biostatistics.med.uoa.gr\/en\/wp-json\/wp\/v2\/tags?post=1477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}